Penetrating at least one phospholipid bilayer of an organelle membrane. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer.

positive regulation of tyrosine phosphorylation of STAT protein

Any process that activates or increases the rate of the introduction of a phosphoric group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.

Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.

intramolecular oxidoreductase activity, interconverting keto- and enol-groups

intramolecular isomerase activity, interconverting keto- and enol-groups

negative regulation of tyrosine phosphorylation of STAT protein

Any process that stops, prevents or reduces the rate of the introduction of a phosphoric group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.

Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin.

negative regulation of megakaryocyte differentiation

Any process that stops, prevents or reduces the rate of megakaryocyte differentiation.

intramolecular oxidoreductase activity, transposing C=C bonds

intramolecular isomerase activity, transposing C=C bonds

Tumor Necrosis Factor alpha biosynthesis

The formation from simpler components of tumor necrosis factor-alpha, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.

Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity.

intramolecular oxidoreductase activity, transposing S-S bonds

intramolecular isomerase activity, transposing S-S bonds

regulation of tumor necrosis factor-alpha biosynthesis