pyruvate dehydrogenase complex (sensu Eukaryota)

pyruvate dehydrogenase complex (lipoamide) (sensu Eukaryota)

Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759).

Formation and development of a dendrite, a freely branching protoplasmic process of a nerve cell.

A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl moiety from geranylgeranyl pyrophosphate to a Rab protein.

Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate (PAPS).

connective tissue growth factor biosynthesis

The formation from simpler components of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGFbeta.

Catalysis of the reaction: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate (PAPS) + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.

Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.

Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase.