negative regulation of interferon-gamma biosynthesis

Any process that stops, prevents or reduces the rate of the formation from simpler components of interferon-gamma.

positive regulation of interferon-gamma biosynthesis

Any process that activates or increases the rate of the formation from simpler components of interferon-gamma.

The covalent or noncovalent linking of a chromophore to a protein.

A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which in converted to a bending motion. May contain two or three dynein heavy chains as well as several light chains.

A filament of myosin found in a muscle cell of any type.

The formation from simpler components of icosanoids, any of a group of C20 polyunsaturated fatty acids.

The formation from simpler components of prostanoids, any compound based on or derived from the prostanoate structure.

DNA repair pathways that tend to increase the endogenous mutation rate.

The directed movement of organelles along microtubules from the cell periphery toward the cell body in nerve cell axons.

Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.

Any microtubule in the cytoplasm of a cell.

early endosome to late endosome transport

The directed movement of substances, in membrane bound vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.

Interacting selectively with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).

A distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: keratin filaments of mammalian epithelial cells; desmin filaments found in cells of muscles of all types; vimentin filaments found in mesenchymal cells; neurofilaments of neurons; and glial filaments found in all types of glial cells.