induction of apoptosis by oxidative stress

The activation, by oxidative stress, of any of the steps required for cell death by apoptosis.

A multimeric enzyme complex that in E. coli is an heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins.

The genetically programmed processes that occur during apoptosis.

Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction, for example ion transport across a membrane.

activation of pro-apoptotic gene products

induction of pro-apoptotic gene products

The conversion of proteins that induce or sustain apoptosis to an active form.

Interacting selectively with glycine, aminoethanoic acid.

Catalysis of the reaction: ATP + H2O = ADP + phosphate, not directly coupled to any other reaction.

negative regulation of survival gene product activity

negative regulation of survival gene products

Any process that stops, prevents or reduces the rate of survival gene product activity; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level.

Interacting selectively with glutamate, the anion of 2-aminopentanedioic acid.

ATPase activity, coupled to transmembrane movement of ions

Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane.

Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, mediated by cytochrome c.