A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle; as the ring contracts it pulls the membrane inwards to divide the contents of the cytoplasm in cytokinesis.

The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.

Any of the spindle microtubules that overlap at the midline of the spindle and are responsible for pushing the poles of the spindle apart.

Any of the spindle microtubules that attach to the kinetochores of chromosomes and maneuver the chromosomes during mitotic or meiotic chromosome segregation.

That part of the cytoplasm that does not contain membranous or particulate subcellular components.

Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway.

Any process that stops, prevents or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity.

Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.

The formation from simpler components of interleukin-12.

Increases the rate of GTP hydrolysis by the GTPase ARF.

The formation from simpler components of interleukin-10.

Interacting selectively with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues.

Any particle of coalesced lipids in the cytoplasm of a cell. May include associated proteins.

The process whereby a relatively unspecialized thymocyte acquires specialized features of a T-helper cell.

A structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.