A belt-like region of very close contact between the plasma membranes of adjacent cells so that the intercellular space is completely occluded. They occur in epithelia and brain endothelia.

The process by which replicated homologous chromosomes are physically separated into two sets during the first division of meiosis. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets.

Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidyl inositol-4,5-bisphosphate + phosphate.

An adherens junction which connects a cell to the extracellular matrix.

The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA.

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that are points of termination of actin filaments.

Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

An adherens junctions formed between a muscle cell and a tendon cell; the muscle and tendon cytoplasmic faces are distinct.

Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+.

The formation from simpler components of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.

A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D1 receptors.

The breakdown into simpler components of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.

A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.