Any process that activates or increases the rate of signal transduction mediated by the JNK cascade.

Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O.

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Interacting selectively with a SMAD signaling protein.

Catalysis of the reaction: P1-P3-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP.

The transfer, from NAD, of ADP-ribose to peptidyl-arginine to form omega-N-(ADP-ribosyl)-L-arginine.

extracellular matrix structural constituent conferring tensile strength

A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.

The chemical reactions involving diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues. DAG is a normal intermediate in the biosynthesis of phosphatidyl phospholipids and is released from them by phospholipase C activity. DAG from phosphatidyl inositol polyphosphates is important in signal transduction.

extracellular matrix structural constituent conferring compression resistance

A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan.

extracellular matrix constituent conferring elasticity

A component of the extracellular matrix that enables the matrix to recoil after transient stretching.

A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments.

Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2.

Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.

The specification and formation of anisotropic intracellular organization or cell growth patterns.