A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins.

The synthesis of either RNA on a template of DNA or DNA on a template of RNA.

Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond.

nucleosome remodeling and histone deacetylation complex

An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in both vertebrates and invertebrates. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.

The synthesis of RNA on a template of DNA.

Catalysis of the cleavage of gelatin types I and V and collagen types IV and V.

Processes involved in starting transcription, which is the synthesis of RNA by RNA polymerases using a DNA template.

The process by which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA.

Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another.

The extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase.

Any complex that mediates dynamic changes in eukaryotic chromatin.

Any process that modulates the frequency, rate or extent of DNA-dependent transcription.