A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle; as the ring contracts it pulls the membrane inwards to divide the contents of the cytoplasm in cytokinesis.

The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.

regulation of immune cell granule exocytosis

Any process that modulates the frequency, rate, or extent of immune cell degranulation.

That part of the cytoplasm that does not contain membranous or particulate subcellular components.

positive regulation of immune cell degranulation

positive regulation of immune cell granule exocytosis

Any process that activates or increases the rate of immune cell degranulation.

The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell.

regulation of mast cell granule exocytosis

Any process that modulates the frequency, rate, or extent of mast cell degranulation.

Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway.

positive regulation of mast cell degranulation

positive regulation of mast cell granule exocytosis

Any process that activates or increases the rate of mast cell degranulation.

Any process that stops, prevents or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity.

Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.

The formation from simpler components of interleukin-12.