A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix.

The action of a molecule that contributes to the structural integrity of tooth enamel.

A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha1, beta1 and gamma1.

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH.

DNA damage response, signal transduction by p53 class mediator

A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the perception of DNA damage.

The breakdown into simpler components of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging.

The chemical reactions involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.

Interacting selectively with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.

The processes that result in the fragmentation by proteolysis of antigens and the association of the resulting peptides with MHC molecules.

Any process that modulates the frequency, rate or extent of cell migration.

Any process that activates or increases the rate of cell migration.

Any process that stops, prevents or reduces the rate of cell migration.

DNA polymerase processivity factor activity

An accessory subunit of DNA polymerase that acts to increase the processivity of polymerization.

Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O.

The processes resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components.