The covalent or conformational alteration of one or more amino acid residues within a protein, resulting in a change in the properties of that protein.

The chemical reactions involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.

oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.

The specific processes that generate the ability of an organism to cause disease in another.

The process of introducing a phosphoric group on to a protein.

Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + H2O2.

Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g.Grb2) or those of their target molecules (e.g. SAM68).

A change in state or activity of an organism (in terms of movement, secretion, gene expression, enzyme production, etc.) in response to temperatures above the optimal temperature for that organism.

negative regulation of protein kinase activity

Any process that stops, prevents or reduces the rate of protein kinase activity.

Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.

A change in state or activity of an organism (in terms of movement, secretion, gene expression, enzyme production, etc.) in response to temperatures below the optimal temperature for that organism.

Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate.