RNA polymerase I, one of three eukaryotic nuclear RNA polymerases, is a multisubunit complex; it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others which are found in all three nuclear RNA polymerases. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Any process that activates or increases the rate of signal transduction mediated by the JNK cascade.

Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O.

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Interacting selectively with a SMAD signaling protein.

Catalysis of the reaction: P1-P3-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP.

extracellular matrix structural constituent conferring tensile strength

A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.

extracellular matrix structural constituent conferring compression resistance

A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan.

The chemical reactions involving diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues. DAG is a normal intermediate in the biosynthesis of phosphatidyl phospholipids and is released from them by phospholipase C activity. DAG from phosphatidyl inositol polyphosphates is important in signal transduction.