The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis.

The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.

The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).

The directed movement of substances into the nucleus.

The breakdown into simpler components of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.

The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.

Any process that modulates the frequency, rate or extent of the chemical reactions involving phosphorus or compounds containing phosphorus.

Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate.

Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

Increases the rate of GTP hydrolysis by the GTPase Rab.

Increases the rate of GTP hydrolysis by the GTPase Ran.

A change in state or activity of an organism as the result of exposure to a xenobiotic compound, a compound foreign to living organisms.

The processes by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location.

Increases the rate of GTP hydrolysis by the GTPase Ras.

A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a photon of UV light.