Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R.

Interacting selectively with a Type II interleukin-1 receptor.

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R.

Blocks the binding of interleukin-1 to the interleukin-1 receptor complex.

Interacting selectively with the interleukin-8 receptor.

epidermal growth factor receptor binding

transforming growth factor alpha receptor ligand

Interacting selectively with the epidermal growth factor receptor.

epidermal growth factor receptor activating ligand activity

macrophage colony stimulating factor receptor binding

macrophage colony stimulating factor receptor ligand

Interacting selectively with the macrophage colony stimulating factor receptor.

Any process that modulates the frequency or rate of macrophage activation.

Interacting selectively with the insulin receptor.

Catalysis of the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.

insulin-like growth factor receptor binding

insulin-like growth factor receptor ligand

Interacting selectively with the insulin-like growth factor receptor.

Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b.

A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages.