The breakdown into simpler components of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.

The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane.

A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle; as the ring contracts it pulls the membrane inwards to divide the contents of the cytoplasm in cytokinesis.

The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.

Any of the spindle microtubules that overlap at the midline of the spindle and are responsible for pushing the poles of the spindle apart.

Any of the spindle microtubules that attach to the kinetochores of chromosomes and maneuver the chromosomes during mitotic or meiotic chromosome segregation.

That part of the cytoplasm that does not contain membranous or particulate subcellular components.

Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway.

Any process that stops, prevents or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity.