posttranslational protein targeting to membrane, translocation

protein translocation during posttranslational protein targeting to membrane

The process by which a protein translocates through the ER membrane posttranslationally.

A membrane associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex. As in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759).

A translocon complex physically associated with a Sec complex.

A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p.

Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade.

Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond.

Catalysis of the hydrolysis of various forms of polymeric ubiquitin-like sequences (e.g. APG8, ISG15, NEDD8, SUMO). Will remove ubiquitin-like sequences from larger leaving groups.

Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates.

Catalysis of ATP-dependent isopeptide bond formation between the carboxy terminal glycine residues of the small ubiquitin-related modifier, SUMO, and a substrate lysine residue, leading to the formation of predominately monosumoylated proteins with modified function.

Combining with an immunoglobulin of an IgG isotype via the Fc region to initiate a change in cell activity.

proteasome core complex, alpha-subunit complex (sensu Eukaryota)

Refers to the subunits that constitute the outer rings of the proteasome core complex, as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759).

proteasome core complex, beta-subunit complex (sensu Eukaryota)

Refers to the subunits that constitute the inner rings of the proteasome core complex, as in, but not restricted to, the eukaryotes (Eukaryota, ncbi_taxonomy_id:2759).