The process arising as the cell progresses toward the end of its lifespan that cause changes cellular metabolism, resulting in a decline in cell function; for example, a decline in the efficiency of protein synthesis.

Catalysis of the reaction: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.

Any process that modulates the frequency, rate or extent of cGMP metabolism.

resolution of meiotic joint molecules as recombinants

The cleavage and rejoining of Holliday junctions to produce two intact molecules in which genetic material has been exchanged.

nucleotide-excision repair, DNA damage recognition

pyrimidine-dimer repair, DNA damage recognition

The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix.

Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester.

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate.

nucleotide-excision repair, DNA duplex unwinding

The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage.

Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.

nucleotide-excision repair, DNA damage removal

The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage.

Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.

The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines.

The fusion of myoblasts to form myotubes.

positive regulation of nucleotide biosynthesis

positive regulation of nucleotide synthesis

Any process that activates or increases the rate, frequency or extent of nucleotide biosynthesis.