Catalysis of the reaction: H2CO3 = CO2 + H2O.

The central region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore.

extrachromosomal circular DNA accumulation during cell aging

extrachromosomal circular DNA accumulation during cell ageing

Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication.

Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins.

Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.

pyrimidine dimer repair via nucleotide-excision repair

The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.

Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+.

Catalysis of the reaction: ATP + L-aspartate = ADP + 4-phospho-L-aspartate.

The maintenance of proper telomeric length by recombinational processes that occur in the absence of an enzymatic activity that adds new telomeric repeats.

Catalysis of the reaction: L-aspartate-4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH + H+.

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

The maintenance of proper telomeric length and structure by processes that affect and monitor the activity of telomeric proteins and the length of telomeric DNA.