malonic semialdehyde oxidative decarboxylase activity

Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+.

Disassembly of the spliceosome with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure.

Disassembly of the U2-type spliceosome with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. The other product is the excised sequence. In cis splicing, this forms a lariat structure.

spliceosomal conformational changes to generate catalytic conformation

Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation.

RNA splicing, via endonucleolytic cleavage and ligation

Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.

Recognition of the intron 5'-splice site by components of the assembling spliceosome.

U2-type spliceosome conformational change to release U4 and U1

Rearrangement of the pre-catalytic spliceosome containing U4 and U1 snRNPs to unpair U4 from U6 and release it from the spliceosomal complex along with U1.

The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules.

Interacting selectively with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.

A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.