heparan sulfate proteoglycan biosynthesis, enzymatic modification

heparan sulphate proteoglycan biosynthesis, enzymatic modification

The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization.

Interacting selectively with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.

Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-desulfoheparin = adenosine 3',5'-bisphosphate + heparin.

Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.

Initiates or upregulates transcription in the presence of zinc.

The chemical reactions involving any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.

The formation from simpler components of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.

The breakdown into simpler components of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids.

The chemical reactions involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

The formation from simpler components of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

The breakdown into simpler components of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.

A class of nuclear body, first seen after silver staining by Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.