oxidized base lesion DNA N-glycosylase activity

Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.

pyrimidine-specific oxidized base lesion DNA N-glycosylase activity

Catalysis of the formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. Enzymes with this activity recognize and remove oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar.

The first division of meiosis in which homologous chromosomes that do not undergo meiotic recombination or form chiasmata are paired and segregated from each other, producing two daughter cells.

meiotic DNA double-strand break processing

During meiosis, the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang.

During meiosis, the assembly of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA.

The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule. These joint molecules contain Holliday junctions on either side of heteroduplex DNA.

negative regulation of cyclic nucleotide metabolism

Any process that stops, prevents or reduces the rate, frequency or extent of cyclic nucleotide metabolism.

Catalysis of the reaction: adenosine + H2O = inosine + NH3.

positive regulation of cyclic nucleotide metabolism

Any process that activates or increases the rate, frequency or extent of cyclic nucleotide metabolism.

Catalysis of the reaction: ATP + adenosine = ADP + AMP.

regulation of cyclic nucleotide biosynthesis

regulation of cyclic nucleotide synthesis

Any process that modulates the frequency, rate or extent of cyclic nucleotide biosynthesis.