A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles.

inner kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.

Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide.

Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins.

Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.

Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin.

Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I)

Catalysis of the hydrolysis of dipeptides.

Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.

Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

translation repressor activity, nucleic acid binding

Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid.

translation repressor activity, non-nucleic acid binding

Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid.

Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins.