Interacting selectively with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.

Catalysis of the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in).

NLS-dependent protein nuclear import complex

A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha and beta-subunits and any protein which has a nuclear localization sequence (NLS). The complex acts to import proteins with an NLS into the nucleus through a nuclear pore.

The process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change.

The process by which oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.

The process by which the axon of a neuron is insulated by nerve ensheathment cells.

Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria.

The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways.

A hexameric protein complex required for the initiation and regulation of DNA replication.

eukaryotic elongation factor-2 kinase regulator activity

Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase.

eukaryotic elongation factor-2 kinase activator activity

Increases the activity of the enzyme eukaryotic elongation factor-2 kinase.

The chemical reactions involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.