positive regulation of GPCR protein signalling pathway

Any process that activates or increases the rate, frequency or extent of G-protein coupled receptor protein signaling pathway activity.

Catalysis of the reaction: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).

negative regulation of Notch signaling pathway

Any process that stops, prevents or reduces the rate, frequency or extent of the Notch signaling pathway.

Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).

positive regulation of Notch signaling pathway

Any process that activates or increases the rate, frequency or extent of the Notch signaling pathway.

Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

negative regulation of S phase of mitotic cell cycle

Any process that stops, prevents or reduces the rate, frequency or extent of S phase of mitotic cell cycle activity.

Catalysis of the linkage of ubiquitin with lysine residues on a target protein. This function may be performed alone or in conjunction with E3, ubiquitin-protein ligase.

Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. Catalyzes the mediation of substrate recognition in ubiquitin-mediated protein degradation; binds directly to the substrate and its cognate E2 (ubiquitin conjugating enzyme).

positive regulation of protein catabolism

positive regulation of protein degradation

Any process that activates or increases the rate, frequency or extent of the breakdown into simpler components of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences. Will remove ubiquitin from larger leaving groups.

Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.