Interacting selectively with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.

A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex.

Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis.

Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin.

transcription of nuclear rRNA large RNA polymerase I transcript

transcription of nuclear rRNA large Pol I transcript

The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template.

Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity.

Enables the directed movement of monoamines, organic compounds containing one amino group, into, out of, within or between cells.

Catalysis of the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in).

Catalysis of the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in).

Catalysis of the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in).

Enables the directed movement of atoms or small molecules with a negative charge into, out of, within or between cells.

histone lysine N-methyltransferase activity (H4-K20 specific)

histone H4 lysine 20-specific methyltransferase activity

Catalysis of the addition of a methyl group onto lysine at position 20 of the histone H4 protein.

The chemical reactions involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.

The chemical reactions involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important.