The nonsense-mediated mRNA decay pathway degrades mRNAs transcribed from genes in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.

The breakdown into simpler components of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.

Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase.

Interacting selectively with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.

The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK.

Interacting selectively with a chemokine, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.

The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK.

Interacting selectively with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.

The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere.

The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of, within or between cells.

Any process that terminates the activity of the active enzyme MAP kinase.

Interacting selectively with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif.

The act of sexual union between male and female, involving the transfer of sperm from male to female.