Any process that stops, prevents or reduces the rate of transcriptional preinitiation complex formation.

The chemical reactions involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).

The action of a molecule that contributes to the structural integrity of the nuclear pore complex.

A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the perception of a biotic stimulus.

Catalysis of the reaction: 6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

The chemical reactions involving sphinganine, D-erythro-2-amino-1,3-octadecanediol.

The chemical reactions involving sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol.

Combining with interleukin-10 to initiate a change in cell activity.

The formation from simpler components of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol.

leukemia inhibitory factor receptor activity

Combining with leukemia inhibitory factor to initiate a change in cell activity.

Combining with oncostatin-M to initiate a change in cell activity.

Combining with prolactin to initiate a change in cell activity.

Enables the directed movement of amines, including polyamines, into, out of, within or between cells. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.

non-G-protein coupled 7TM receptor activity

Enables the directed movement of acetylcholine into, out of, within or between cells. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.

The chemical reactions involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.