Chromothripsis Explorer

Analyze and visualize chromothripsis patterns across ~2,600 human cancers

Chromothripsis rates in human cancers

The barplot on the right depicts the chromothripsis rates in the cancer types selected that satisfy the minimum values indicated on the left-hand menu.


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Relationship between ploidy, purity, CN oscillations and SVs involved in chromothripsis


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Find cases of interest quickly!

Click on the button below to browse detailed information for chromsomes 1:22 and X for all PCAWG tumors.

Use the filters on top of the columns to find tumors of your interest and explore them interactively using the circos plots below.


Interactive circos plots reporting SNVs, indels, total CNV, minor CN (LOH), and SV calls

The selection boxes below only affect the plots below them (not the bubble plots above)

Circos plot options
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Patient information, values for the statistical metrics, and additional information


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Acknowledgements


The results published here are partly based upon data generated by The Cancer Genome Atlas and obtained from the Database of Genotypes and Phenotypes (dbGaP) with accession number phs000178.v8.p7.


Information about TCGA can be found at http://cancergenome.nih.gov. We thank the Research Information Technology Group at Harvard Medical School for providing computational resources. This work was supported by grants from the Ludwig Center at Harvard (I.C.C., J.K.L., and P.J.P.).


This project has received funding from the European Union’s Framework Programme For Research and Innovation Horizon 2020 (2014-2020) under the Marie Curie Sklodowska-Curie Grant Agreement No. 703543 (I.C.C.).


This work was performed as part of the PCAWG Structural Variation Working Group.


This site was designed by Isidro Cortes-Ciriano (isidrolauscher at gmail.com).

Shiny App deployment by Scott Oullette

In all Supplementary Data Files intrachromosomal SVs are depicted as arcs with the breakpoints represented by black points, whereas the breakpoints corresponding to interchromosomal SVs are depicted as colored points. Duplication-like SVs, deletion-like SVs, head-to-head and tail-to-tail inversions are depicted in blue, orange, black, and green, respectively. The value for the statistical criteria described above for each event is provided below its representation.